The cellular basis of allograft rejection in vivo. II. The nature of memory cells mediating second set heart graft rejection.
نویسندگان
چکیده
منابع مشابه
The cellular basis of allograft rejection in vivo. II. The nature of memory cells mediating second set heart graft rejection
An adoptive transfer system was used to study the cellular basis of memory in animals immunized by grafting with major histocompatibility complex incompatible tissue. Memory was characterised by a large (greater than 100 fold) increase in the potency of lymphocytes to precure graft rejection. This increase in potency endured for at least 1 yr after sensitization. The memory cells were shown to ...
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The nature of the cells required for first-set graft rejection in vivo was examined by using an adoptive transfer system to restore heart-graft rejection in irradiated rats. Highly purified inocula of peripheral T lymphocytes were shown to quantitatively account for the restorative ability of adoptively transferred cells. These T cells were shown to be long-lived small lymphocytes which are not...
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A str iking feature of i m m u n e responses m o u n t e d against the major h is tocompat i bi l i ty complex (MHC) t in vivo is the long dura t ion of the specific memory of pr ior exposure to these antigens. Second-set skin graft rejection can be demons t r a t ed several years after p r ima ry sensi t izat ion in mice and rats (1). Adop t ive transfer of second-set rejection to naive animal...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1978
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.148.4.890